AVA Conference Brisbane 2018

Chronic cellular inflammation from oxidative stress leads to a wide variety of diseases, including obesity, chronic infections and cancers. Chronic inflammation occurs when the tissues or organs receive inflammatory “mediator” messages that cause them to react as though the “trigger” or pathogen was still present. Rather than repairing themselves, these cells remain in an ongoing state of inflammation that can wax and wane for an entire lifetime. As a result, tissues become deficient in antioxidant mediators, such as malonedialdehyde, glutathione, cysteine, ascorbic acid and other antioxidant vitamins, which is associated with poor clinical outcome. An important aspect of this topic deals with prevention and the early recognition of the cellular changes that lead to cancer. The factors involved include: controlling chronic obesity and weight control with caloric restriction and by increasing sirtuin-based foods which help increase lifespan; feeding fat-fighting functional foods; feeding the needed rather than package recommended amounts; need for high quality bioavailable novel proteins; feeding antiangiogenic foods to help shrink fat and cancers; accepting genetic predisposition to obesity; regulation of gene expression through diet; food sensitivities/intolerances; and weight gain from spaying and neutering, and decreased physical activity and exercise. These effects also pertain to the lipid oxidation and risk of rancidity in pet foods with their higher fat and oil content.